Henkel: Engineering Manager

3 weeks ago
Competitive: Henkel: About this Position Lead the Maintenance & Engineering standardization and the planned & corrective maintenance in the site. Roll out best practice... Nairobi, Nairobi Area, Kenya

Intestinal microbiome profile of the brown rock sea cucumber (<em>Holothuria glaberrima</em>) using ITS and 16S rDNA amplicons from direct mechanical, enzymatic, and chemical metagenomic extraction

3 weeks 1 day ago
Rene Nieves-Morales
Using direct mechanical, enzymatic, and chemical extraction methods, the intestinal microbiome of the marine invertebrate Holothuria glaberrima was obtained. ITS and 16S rDNA regions were sequenced to enrich and investigate the prokaryotic and fungal diversity profiles from different anatomical regions within the sea cucumber's intestinal biology.

Assessing Olfactory Acuity in Primary Ciliary Dyskinesia with the <em>RSPH4A</em> Founder Mutation

3 weeks 1 day ago
Miguel A De Jesús
Background/Objectives: Primary Ciliary Dyskinesia (PCD) is a rare genetic condition characterized by compromised mucociliary clearance and chronic respiratory manifestations. Anosmia, or the loss of smell, is a lesser-known but clinically relevant symptom that can significantly impact patient safety, nutritional status, and the overall quality of life. The RSPH4A (c.921+3_921+6delAAGT) founder mutation is highly prevalent among Puerto Rican individuals with PCD and may carry distinct phenotypic...

Ergosterol Peroxide Disrupts Triple-Negative Breast Cancer Mitochondrial Function and Inhibits Tumor Growth and Metastasis

3 weeks 1 day ago
Aliyah L Bocachica-Adorno
Ergosterol peroxide (EP) triggers apoptosis pathways by inducing reactive oxygen species (ROS) in TNBC cell lines. Excess ROS production is associated with major damage to mitochondria. We hypothesized that EP may act through ROS-induced mitochondrial dysfunction. Therefore, we performed a series of assays that assessed mitochondrial membrane potential (MMP), cellular respiration, and glycolysis in TNBC models. Cardiomyocytes derived from human-induced pluripotent stem cells were chosen as a...

The Emerging Role of Circulating T Follicular Helper Cells in Dengue Virus Immunity: Balancing Protection and Pathogenesis

3 weeks 1 day ago
Paola N Flores-Pérez
Flaviviruses are a group of viruses transmitted mainly by mosquitoes and ticks, causing severe diseases in humans. Examples include dengue, Zika, West Nile virus, and yellow fever. They primarily affect individuals in tropical and subtropical regions, causing public health problems such as epidemic outbreaks and significant economic burdens due to hospitalizations and treatments. They share antigens, leading to cross-reactivity where antibodies generated against one flavivirus can react with...

A Modified Variant of <em>Fasciola hepatica</em> FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

3 weeks 1 day ago
Riseilly Ramos-Nieves
CONCLUSIONS: Our results demonstrate that mFhSAP-2 retained its immunogenicity and Th1-polarizing properties, which were enhanced by the Montanide ISA50 adjuvant. The present study highlights the feasibility of inducing Th1-associated immune responses in mice using mFhSAP-2 as an antigen. Further studies are required to assess the potential application of the mFhSAP-2+ISA50 formulation as a vaccine against F. hepatica in natural hosts such as cattle and sheep, which could contribute to improved...

Pseudomonas Reinfection in a Patient With Primary Ciliary Dyskinesia: How a Toothbrush Could Make You Sick

3 weeks 1 day ago
Jose Colon-Soto
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterized by impaired mucociliary clearance, leading to recurrent respiratory tract infections, chronic rhinosinusitis, and progressive bronchiectasis. Pseudomonas aeruginosa is a common pathogen associated with poorer clinical outcomes in patients with PCD. While environmental sources of P. aeruginosa are well-documented in cystic fibrosis (CF) patients, to our knowledge, this is the first reported case implicating...

Henkel: Junior Computer System Engineer

3 weeks 1 day ago
Competitive: Henkel: About this Position Technology is at the heart of everything we do, and as a Junior Systems Engineer, you'll play a vital role in ensuring our comp... Hemel Hempstead, England, United Kingdom