DMU: Grants Administrator

1 month ago
Range: $80,000 - $90,000: DMU: Join DMU as a Grants Manager and help drive impactful research, support faculty, and shape the future of medicine and health sciences. West Des Moines, Iowa

The Bactericide Effects of Chitosan When Used as an Indicator of Chlorine Demand

1 month ago
Josefine Molina-Pinna
The Miradero Water Treatment Plant (MWTP) in Mayagüez, Puerto Rico, uses sodium hypochlorite (SH) as a disinfectant. However, SH reacts with humic substances present in surface water, forming disinfection by-products (DBPs) regulated by the U.S. EPA. This study evaluated whether chitosan, a biopolymer with known bactericidal properties, could reduce chlorine demand and improve disinfection. Chitosan, with a 75% degree of deacetylation and a molecular weight of 460 kDa, was solubilized in four...

Risk-aware electricity dispatch with large-scale distributed renewable integration under climate extremes

1 month ago
Luo Xu
Distribution networks, with large-scale integration of distributed renewable resources, particularly rooftop solar photovoltaic systems, represent the most extensive yet vulnerable components of modern electric power systems during climate extremes such as hurricanes. However, existing day-ahead electricity dispatch approaches primarily focus on the transmission network and lack the capability to manage the spatiotemporal risks associated with the vast distribution networks, which can...

Upregulation of MMP3 Promotes Cisplatin Resistance in Ovarian Cancer

1 month ago
Mariela Rivera-Serrano
Most women with ovarian cancer (OC) develop resistance to platinum chemotherapy, posing a significant challenge to treatment. Matrix metalloproteinase 3 (MMP3) is overexpressed in High-Grade Serous Ovarian Cancer (HGSOC) and is associated with poor survival outcomes; however, its role in platinum resistance remains underexplored. We evaluated the baseline and cisplatin-induced MMP3 transcript and protein levels in cisplatin-resistant OC cells, revealing significantly higher MMP3 levels in...

The Bactericide Effects of Chitosan When Used as an Indicator of Chlorine Demand

1 month ago
Josefine Molina-Pinna
The Miradero Water Treatment Plant (MWTP) in Mayagüez, Puerto Rico, uses sodium hypochlorite (SH) as a disinfectant. However, SH reacts with humic substances present in surface water, forming disinfection by-products (DBPs) regulated by the U.S. EPA. This study evaluated whether chitosan, a biopolymer with known bactericidal properties, could reduce chlorine demand and improve disinfection. Chitosan, with a 75% degree of deacetylation and a molecular weight of 460 kDa, was solubilized in four...

Surface-Enhanced Raman Spectroscopy on Gold Nanoparticle for Sperm Quality Discrimination

1 month ago
Yeira P Lopez-Lora
Spermatozoa were isolated from the seminal fluid using washing (wash), post-capacitation (POS), and swim-up (SU) techniques, followed by analysis through Surface-Enhanced Raman Spectroscopy (SERS). Density gradient and swim-up methods were applied to 35 semen samples to validate sperm quality. The resulting spectra showed notable variations at 408 cm^(-1) (S-S stretch attributed to lysozyme) and 728 cm^(-1) (associated with DNA alterations and methylation). These spectral markers were...

Single-Anesthesia Event for Lung Nodule Marking and Minimally Invasive Sublobar Resection

1 month ago
Noah Gordon
Background: Non-small cell lung cancer (NSCLC) accounts for a significant number of new lung cancer diagnoses each year, which, if identified early, may be surgically removed with curative intent. It is also the most common indication for a sublobar resection due to its equal efficacy in carefully selected patients. From the time of diagnosis to surgery, however, traditionally, there are three separate anesthesia-dependent events: (1) diagnostic bronchoscopy plus lymph node staging, (2) lung...

Techniques and factors for reducing chronic neuropathic pain: A review

1 month ago
Damien P Kuffler
Nerve trauma commonly results in chronic neuropathic pain. This is by triggering the release of proinflammatory mediators from local and invading cells that induce inflammation and nociceptive neuron hyperexcitability. Even without apparent inflammation, injury sites are associated with increased inflammatory markers. This review focuses on how it might be possible to reduce neuropathic pain by reducing inflammation. Physiologically, pain is resolved by a combination of the out-migration of...

Pediatric kidney replacement therapies in low-to-middle income countries: a review and white paper

1 month ago
Rajiv Sinha
Acute kidney injury (AKI) disproportionately impacts children in low- and middle-income countries (LMICs), where up to 85% of AKI cases occur. As for pediatric chronic kidney disease (CKD), the true burden in LMICs remains unclear, as many cases go undiagnosed early, and other children succumb without adequate treatment. Unfortunately, these disparities result from limited access to kidney replacement therapy (KRT), kidney laboratory and imaging resources, healthcare provider shortages, and...