A Rare Manifestation of Systemic Lupus Erythematosus: A Case of Lupus Cystitis in Puerto Rico

2 months 2 weeks ago
Luis Xavier Mayol-Velez
Lupus cystitis is an uncommon, yet serious complication of systemic lupus erythematosus (SLE) marked by inflammation of the bladder and associated with significant urinary tract manifestations. The diagnosis of lupus cystitis can be very challenging as it often appears before the diagnosis of lupus has been established. This report presents the case of a 36-year-old male patient with a history of SLE admitted with gastrointestinal (GI) and urinary symptoms who was subsequently diagnosed with...

Muonium fine structure: theory update, tests of Lorentz violation, and experimental prospects

2 months 2 weeks ago
Philipp Blumer
We review the status of the QED calculations for the muonium 2 S 1 / 2 - 2 P 3 / 2 energy interval and provide the updated theoretical value of 9874.357(1) MHz . Additionally, we present a model for probing Lorentz-violating coefficients within the Standard Model Extension framework using the fine structure measurement in the presence and absence of a weak external magnetic field, enabling novel tests of CPT and Lorentz symmetry. Using Monte Carlo simulations, we estimate that a precision...

IgA-driven neutrophil activation underlies post-Zika severe dengue disease in humans

2 months 2 weeks ago
Jaime A Cardona-Ospina
The four dengue virus serotypes (DENV1-4) and the related Zika flavivirus (ZIKV) are major public health concerns worldwide. Primary immunity against ZIKV increases the risk of a subsequent severe DENV2 infection, presenting a significant challenge for developing safe and effective ZIKV vaccines. However, the mechanisms driving this phenomenon remain unclear. Leveraging our long-standing Pediatric Dengue Cohort Study in Nicaragua, we show that serum anti-NS1 IgA antibodies elicited after a...

Communities Started the End of the HIV Epidemic: Experiences With and Recommendations for Conducting Community-Engaged HIV Implementation Research

2 months 2 weeks ago
Carlos E Rodriguez-Diaz
Communities of people living with or impacted by HIV have been at the forefront of HIV research, from identifying the health priorities to advocating for the development and implementation of interventions that benefit affected populations and individuals. Community engagement is considered fundamental for successful implementation of science projects. However, researchers have acknowledged the limited guidance on community engagement for implementation science research. Some recommendations...

Language Justice in Implementation Science: Experiences Working With Latinxs to End the HIV Epidemic

2 months 2 weeks ago
Carlos E Rodriguez-Diaz
HIV continues to affect populations made socially vulnerable, including Latinx groups. For Spanish-speaking people, there are additional social factors that increase their vulnerability. How we communicate, mainly language, is fundamental to achieving expected outcomes when implementing health interventions. In this article, we address the issue of language justice and how it has been applied to meet the needs of Spanish-speaking Latinx populations in different locations in the United States...

Association between Stressors after Hurricanes Irma and María and Psychological Distress in Patients with Active Breast and Colorectal Cancer Treatment

2 months 2 weeks ago
Hérmilis Berríos
CONCLUSION: Breast and colorectal cancer patients experienced heightened psychological distress due to exposure to various hurricane-related stressors. It is crucial to prioritize an action plan that addresses disaster preparedness, response, and the mental well-being of vulnerable populations like cancer patients to enhance their overall health and resilience.

Long-Term Outcomes of Short versus Long Dental Implants with Sinus Lift in Atrophied Posterior Maxillae: A Systematic Review and Meta-Analysis

2 months 2 weeks ago
Brayann O Alemán
This study aimed to evaluate implant outcomes, including success or survival, complications, and marginal bone loss (MBL), in randomized controlled trials (RCTs), comparing short versus long implants with sinus augmentation (SA) after 5 or more years of loading. The objective was to update the qualitative and quantitative evidence on this topic and provide a comprehensive analysis of the previously identified implant outcomes. Electronic searches were conducted in 4 scientific databases from...

Physical Activity in Puerto Rico: Recommendations for Research, Surveillance, and Policy Development

2 months 2 weeks ago
Raúl D Gierbolini-Rivera
CONCLUSION: The PR Country Card is a tool to raise awareness and identify surveillance, research, and policy gaps. Recommendations include establishing a dedicated PR health monitoring system, integrating PA into PR national public health plans, and establishing an interinstitutional coalition for PA research (in PR). Multi-sector efforts from policymakers, researchers, and stakeholders are essential for meaningful progress in improving PA levels and public health in PR.

Cellular dedifferentiation. Revisiting Betty Hay's legacy

2 months 2 weeks ago
Alejandra Beltrán-Rivera
The concept of mature specialized cells and the stability of the differentiated state was fundamentally challenged by Elizabeth Hay's groundbreaking observations on amphibian limb regeneration, published in 1959. Building on previous work by C.S. Thornton, she discovered that muscle cells could dedifferentiate and transform into progenitor cells within the regeneration blastema reshaping our understanding of cell differentiation. This pivotal finding reshaped our understanding of cell...