Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated β-cell Dysfunction in Male Mice

2 months 2 weeks ago
Abhishek Roy
Chronically elevated circulating excess free fatty acids (i.e. lipotoxicity) is a pathological process implicated in several metabolic disorders, including obesity-driven Type 2 diabetes (T2D). Lipotoxicity exerts detrimental effects on pancreatic islet β-cells by reducing glucose-stimulated insulin secretion (GSIS), altering β-cell transcriptional identity, and promoting apoptosis. While β-cell-derived small extracellular vesicles (sEV) have been shown to contribute to β-cell failure in T2D,...

Henkel: Eumseong Plant Quality Intern

2 months 2 weeks ago
Competitive: Henkel: About this position This position supports general quality work and testing for products in QC laboratory at Eumseong plant and provides opportunit... Eumseong, Chungcheongbuk-Do, Korea, South

North Carolina Central University - Department of Biological and Biomedical Sciences : Director, Julius L. Chambers Biomedical/Biotechnology Research Institute (JLC-BBRI)

2 months 2 weeks ago
Commensurate with education and experience: North Carolina Central University - Department of Biological and Biomedical Sciences : NCCU invites distinguished applicants for the role of Director, Julius L. Chambers Biomedical/Biotechnology Research Institute. Durham and Kannapolis, North Carolina (US)

A new species of Microledrida Fowler from Curaçao (Hemiptera: Fulgoromorpha: Cixiidae)

2 months 2 weeks ago
Matthé Cornelis DE Haas
As part of a review of the Auchenorrhyncha of the (former) Dutch Antilles, a new species in the genus Microledrida, Microledrida malpaisa sp. nov., is described from Curaçao. The novel taxon differs from other species in the genus in colouration and form of its male genitalia, especially the shape of the anal tube and the number and shape of the spinal processes of the phallotheca. The records from Curaçao, a record from Panama, and iNaturalist records from Costa Rica comprise the southernmost...

Psychiatric genetics in the diverse landscape of Latin American populations

2 months 2 weeks ago
Estela M Bruxel
Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked...