Aggregator

The small G-protein Rac1 is a central player in cancer progression and metastatic dissemination. Rac1 has been established as a bona fide effector of receptor tyrosine kinases, acting as a signaling node for motility, invasiveness, mitogenesis, and gene expression. Previous studies demonstrated that Rac1 is hyperactivated in aggressive cellular models of prostate cancer. Here, we show that CRISPR/Cas9-based knockout of Rac1 leads to impaired prostate cancer cell proliferation and migration....

Global risk maps are an important tool for assessing the global threat of mosquito and tick-transmitted arboviral diseases. Public health officials increasingly rely on risk maps to understand the drivers of transmission, forecast spread, identify gaps in surveillance, estimate disease burden, and target and evaluate the impact of interventions. Here, we describe how current approaches to mapping arboviral diseases have become unnecessarily siloed, ignoring the strengths and weaknesses of...

Excessive intracellular labile iron levels exacerbate reactive oxygen species (ROS) production through the Fenton reaction, leading to lipid peroxidation and ferroptotic cell death. Ferroptosis is commonly induced experimentally using chemical inhibitors such as RSL3 (a GPX4 inhibitor) or erastin (an inhibitor of the cystine-glutamate exchanger, Xc-) or by cysteine deprivation. However, these methods often fail to replicate the physiological complexity of ferroptosis and are associated with...

Competitive: University of Texas MD Anderson Cancer Center: MISSION STATEMENT The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world th... Houston, Texas

See job description.: University of Nevada, Reno: Chair, Physiology And Cell Biology R0146237 Medicine, Reno - University of Nevada School of Medicine The University of Nevada, Reno (UNR) a Reno, Nevada (US)

Baylor College of Medicine: ... Houston, TX

Baylor College of Medicine: ... Houston, TX

Baylor College of Medicine: ... Houston, TX

Baylor College of Medicine: ... Houston, TX

Competitive: Henkel: About this Position This Regional NPI (New Product Introduction) Manager is responsible for driving innovation across the regional supply chain to... Gangnam, Seoul, Korea, South

Commensurate with education and experience: Mohammed VI Polytechnic University: We are seeking a highly motivated postdoctoral researcher to join an interdisciplinary research project focused on understanding the ecological ... Ben Guérir

Competitive: City University of Hong Kong: Global Scholar Recruitment Campaign City University of Hong Kong (CityUHK) is one of the world’s leading universities, known for innovation, creati... Hong Kong (HK)

$385,000 - $405,000: University of California, Office of the President: The University of California, Office of the President, invites nominations and applications for the role of Associate Vice President, National Labo... Oakland, California

Competitive: Department of Biology and Neuroscience Program, Brandeis University: The Department of Biology and the Graduate School of Arts and Sciences at Brandeis University invites applications for a full-time Director of the ... Waltham, Massachusetts (US)

The working conditions are governed by the collective agreement: Université de Sherbrooke, Service des ressources humaines: The Université de Sherbrooke invites applications for two tenure-track faculty positions in Molecular and Cellular Biology in the Department of Bio... Sherbrooke (City), Quebec

Competitive: The Hong Kong Polytechnic University: THE HONG KONG POLYTECHNIC UNIVERSITY With over 85 years of rich heritage, The Hong Kong Polytechnic University (PolyU) has evolved alongside societ... Hong Kong (HK)

CONCLUSION: This case represents a unique instance of concurrent chondroblastoma and supraspinatus tear in adolescents with its successful surgical management presented as a novel approach without prior literature.

Chronically elevated circulating excess free fatty acids (i.e. lipotoxicity) is a pathological process implicated in several metabolic disorders, including obesity-driven Type 2 diabetes (T2D). Lipotoxicity exerts detrimental effects on pancreatic islet β-cells by reducing glucose-stimulated insulin secretion (GSIS), altering β-cell transcriptional identity, and promoting apoptosis. While β-cell-derived small extracellular vesicles (sEV) have been shown to contribute to β-cell failure in T2D,...

W2: Max Planck Institute for Polymer Research (MPIP): The Max Planck Institute for Polymer Research (MPIP) invites applications for Max Planck Research Group Leaders (W2 Federal Civil Service Remunera... Mainz (DE)

Commensurate with education and experience: Northeast Ohio Medical University: Are you a high-achieving biomedical researcher or educator ready to take the next step toward an academic career? Rootstown, Ohio