Long-term editing of brain circuits in mice using an engineered electrical synapse

2 months 1 week ago
Elizabeth Ransey
Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical signaling between two cellular components of a mammalian neural circuit remain sparse. Here, we engineered an electrical synapse composed of two connexin proteins found in Morone americana (white perch fish) - connexin34.7 and connexin35 - to accomplish mammalian circuit modulation. By exploiting protein mutagenesis, devising a new...

Isoxazole and Pyrazole Derivatives of 28-Oxo-Allobetulone Target Viral Membrane Glycoprotein Hemagglutinin

2 months 1 week ago
Irina E Smirnova
A series of [2,3]-isoxazoles and pyrazole annulated with the A-ring of lupane, oleanane, and ursane type triterpenoids was synthesized and screened for antiviral activity. It was found that 28-oxo-allobetulone isoxazole 4 with IC(50) 7.3 μM (SI 86) and pyrazole 5 with IC(50) 62.1 μM (SI 10) demonstrated a high inhibitory activity against Flu A/Puerto Rico/8/34 (H1N1) strain virus. The compounds 4 and 5 appeared to be the most active at the earlier stages of the viral cycle (0-2 h post...

Novel hybrid transfer neural network for wheat crop growth stages recognition using field images

2 months 1 week ago
Aisha Naseer
Wheat is one of the world's most widely cultivated cereal crops and is a primary food source for a significant portion of the population. Wheat goes through several distinct developmental phases, and accurately identifying these stages is essential for precision farming. Determining wheat growth stages accurately is crucial for increasing the efficiency of agricultural yield in wheat farming. Preliminary research identified obstacles in distinguishing between these stages, negatively impacting...

Management Approaches to Spastic Gait Disorders

2 months 1 week ago
Sheng Li
Spastic gait presents clinically as the net mechanical consequence of neurological impairments of spasticity, weakness, and abnormal synergies and their interactions with the ground reaction force in patients with upper motor neuron syndromes and with some neuromuscular diseases. It is critical to differentiate whether the primary problem is weakness or spasticity, thus better understanding different phenotypes of spastic gait disorders. Pelvic girdle abnormality plays a pivotal role in...

Henkel: Sales/ Application Engineer - AP

2 months 1 week ago
Competitive: Henkel: About this Position Leading and executing sales account plans (technical and commercial) in defined territory. What you´ll do Support SBU/ sub-segm... Johannesburg-Bedfordview, Gauteng, South Africa

Henkel: Engineering Manager

2 months 1 week ago
Competitive: Henkel: About this Position This role offers a Monday through Friday work schedule from 7AM to 4PM. The Salt Lake City, UT Henkel manufacturing facility is... Salt Lake City, Utah, United States

Henkel: Assistant Manager- Quality

2 months 1 week ago
Competitive: Henkel: About this Position You shall be an integral part of the Plant Quality team and shall be responsible for quality assurance related activities in th... Rudrapur, Uttaranchal, India