Biomedical Publications FROM PR

Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, and salivary glands. HNC represents a significant public health challenge, and recent reports indicate an increment in the incidence of HNC in young adults. In 2020, approximately 377,700 new HNC cases and 177,800 HNC-related deaths were reported globally. Major risk factors include tobacco smoking, alcohol consumption, and...

CONCLUSIONS: This case demonstrates that the CBP^(®) orthopedic chiropractic treatment approach may represent an effective method to treat abnormal spinal alignment and posture. This study adds to the literature regarding conservative methods of treating spine pain and spinal disorders.

BACKGROUND: Effect of apolipoprotein E (APOE) on Alzheimer's disease and related dementias (ADRD) risk is heterogeneous across populations, with scarce data on Hispanics/Latinos.

Calvarial sutures and skull-shape deformities have been recognized since ancient times, but their direct link to premature suture fusion was first established in the 19th century. The earliest surgical attempts for craniosynostosis emerged in 1890 with strip craniectomy, though early outcomes were largely unsuccessful. Surgical progress stagnated for decades due to complications and skepticism surrounding these techniques. The 20th century brought significant advancements, beginning with...

A case of a 63-year-old woman with hypertension, chronic kidney disease, and osteoporosis who presented with acute coronary syndrome and new-onset heart failure. Angiography revealed a completely obstructed abdominal aorta, with no circulation to the femoral arteries and perfusion only through collateral vessels. This severe peripheral arterial disease (PAD) was diagnosed during her hospitalization, raising the question of why it had remained undiagnosed for years and whether earlier detection...

CONCLUSIONS: SPECT/CT and PET/CT might have an added value in the diagnosis of patients with mild/moderate TBI. However, a larger study is required to develop new predictive TBI model systems that include functional and molecular nuclear medicine neuroimaging, and physiologic parameters, in the TBI diagnostic algorithm for veterans with probable TBI. The mismatch between perfusion and metabolism might be suggesting the possibility of up-regulation of cerebral glucose transporters/receptors to...

The intensification of climate change poses significant threats to coastal regions worldwide, manifesting in increased storm frequency, sea level rise, and consequent flooding risks. This study addresses the urgent need for innovative monitoring strategies by introducing an advanced coastal hazard monitoring system specifically designed for areas with underdeveloped monitoring infrastructure. Employing a blend of traditional methods and cutting-edge technologies, including the Segment Anything...

Background: Examining sedentary time (ST) by disaggregating the day into periods such as before, during, and after preschool allows interventionists to understand when sedentary behaviors are most severe. This study aimed to determine if there are sex differences in ST before, during, and after preschool hours in US preschoolers. Methods: A secondary analysis of a two-cohort study with a sample size of 292 preschoolers (67% African Americans/Blacks; 100% from low-income families) was used....

Identifying the genes and mutations that drive phenotypic variation and which are subject to selection is crucial for understanding evolutionary processes. Mormon Fritillary butterflies (Speyeria mormonia) exhibit a striking wing color polymorphism throughout their range: typical morphs bear silver spots on their ventral surfaces and can co-occur with unsilvered morphs displaying a dull coloration.¹ Through genome-wide association studies in two polymorphic populations, we fine-map this...

Lake Balaton, a large shallow freshwater lake in Hungary, exhibits diverse bacterioplankton communities influenced by various environmental factors. This study aims to evaluate the bacterial diversity in Lake Balaton using the long-read approach to 16 S rRNA gene sequencing. Water samples were collected from a wide network of 33 locations across the lake's four basins and analyzed for bacterial community composition. Sequencing results revealed a high taxonomic diversity with significant zonal...

Although global research on the 5Cs model of Positive Youth Development (PYD; competence, confidence, connection, character, and caring) has expanded in recent years, there is a lack of understanding about distinct and consistent PYD profiles across youth from diverse socio-cultural contexts. To address this gap, this study utilized a person-oriented analytic approach to examine the PYD profiles of 11,481 emerging adults (M^(age) = 21.77; SD^(age) = 2.74; 68.66% females) from 21 countries in...

CONCLUSION: Many patients/parents perceived prognostic disclosure to be suboptimal and identified specific features underpinning poor-quality prognostic communication. These findings will inform future collaborative research with patients, parents, and multidisciplinary clinicians to codesign an intervention that individualizes prognostication to align with patient/parent preferences for receiving information and fostering connection.

White cord syndrome (WCS) is a rare but serious postoperative complication after spinal decompression surgery. Risk factors such as advanced age, ossification of the posterior longitudinal ligament (OPLL), and major surgery may have predisposed this patient to develop WCS. This report discusses a 72-year-old Hispanic male patient with cervical stenosis due to OPLL who underwent posterior cervical decompression and fusion. After laminectomy and decompression were done, neuromonitoring signals...

Oncogenic translocations involving the MET gene have been reported in several cancer types, but detailed clinicogenomic characterization of these cancers is not well defined. In addition, prospective clinical trials evaluating the antitumor activity of MET inhibitors in MET rearrangement-positive cancers are limited. Here, in a pan-cancer analysis of >46,000 solid tumors with comprehensive genomic profiling, we identified oncogenic MET rearrangements in ~0.04% of cancers. Preliminary analysis...

CONCLUSION: In this cohort study, we revealed the relationship between SASP markers and HIV-1 persistence. Future interventions targeting the senescence pathways may impact HIV-1 persistence.

Electrical signaling across distinct populations of brain cells underpins cognitive and emotional function; however, approaches that selectively regulate electrical signaling between two cellular components of a mammalian neural circuit remain sparse. Here, we engineered an electrical synapse composed of two connexin proteins found in Morone americana (white perch fish) - connexin34.7 and connexin35 - to accomplish mammalian circuit modulation. By exploiting protein mutagenesis, devising a new...

Wheat is one of the world's most widely cultivated cereal crops and is a primary food source for a significant portion of the population. Wheat goes through several distinct developmental phases, and accurately identifying these stages is essential for precision farming. Determining wheat growth stages accurately is crucial for increasing the efficiency of agricultural yield in wheat farming. Preliminary research identified obstacles in distinguishing between these stages, negatively impacting...

Spastic gait presents clinically as the net mechanical consequence of neurological impairments of spasticity, weakness, and abnormal synergies and their interactions with the ground reaction force in patients with upper motor neuron syndromes and with some neuromuscular diseases. It is critical to differentiate whether the primary problem is weakness or spasticity, thus better understanding different phenotypes of spastic gait disorders. Pelvic girdle abnormality plays a pivotal role in...

Dynamic catalytic structures at the catalyst-electrolyte interface pose significant challenges in accurately identifying active sites and establishing precise structure-activity relationships essential for catalyst design and performance optimization. Herein, we unveil the dynamic structural evolution of Cu-N-C single-atom catalysts (SACs) under electrochemical conditions, elucidating the critical role of the electrochemical coupled field. Using hybrid-solvation constant potential simulations,...

CONCLUSION: While rare, sarcoma can be encountered in patients with LS, particularly those with germline MSH2 mutation. LS-associated sarcomas occur significantly earlier, carry a favorable outcome, and demonstrate the potential for durable response with immunotherapy.