Evaluation of the influenza vaccine protection in the house dust mite-induced chronic allergic asthma mice model and the evaluation of squalene oil in water emulsion as an adjuvant candidate

2 months 1 week ago
So Yeon Ahn
CONCLUSION: The immune response after split inactivated A/PR8 vaccine differed between asthma and naïve mice, particularly in terms of antibody activity and T cell populations. This study enhances our understanding of how asthma status may influence the effectiveness of influenza vaccine and offers insights into the AddaVax™-induced eosinophilic inflammation, guiding the development of virus vaccine strategies for both healthy individuals and asthma patients.

Global Profiles of Positive Youth Development: A Person-Oriented Analysis among Emerging Adults Living in 21 Countries

2 months 1 week ago
Jet Uy Buenconsejo
Although global research on the 5Cs model of Positive Youth Development (PYD; competence, confidence, connection, character, and caring) has expanded in recent years, there is a lack of understanding about distinct and consistent PYD profiles across youth from diverse socio-cultural contexts. To address this gap, this study utilized a person-oriented analytic approach to examine the PYD profiles of 11,481 emerging adults (M^(age) = 21.77; SD^(age) = 2.74; 68.66% females) from 21 countries in...

"We Were Still Left in the Back Field, Not Knowing": Pediatric Cancer Patients and Parents Describe Obstacles to Prognostic Communication

2 months 1 week ago
Adriana Areizaga Ayala
CONCLUSION: Many patients/parents perceived prognostic disclosure to be suboptimal and identified specific features underpinning poor-quality prognostic communication. These findings will inform future collaborative research with patients, parents, and multidisciplinary clinicians to codesign an intervention that individualizes prognostication to align with patient/parent preferences for receiving information and fostering connection.

White Cord Syndrome: Myelopathy Caused by an Ossified Posterior Longitudinal Ligament After Posterior Cervical Laminectomy and Fusion

2 months 1 week ago
Ashlie Maldonado-Pérez
White cord syndrome (WCS) is a rare but serious postoperative complication after spinal decompression surgery. Risk factors such as advanced age, ossification of the posterior longitudinal ligament (OPLL), and major surgery may have predisposed this patient to develop WCS. This report discusses a 72-year-old Hispanic male patient with cervical stenosis due to OPLL who underwent posterior cervical decompression and fusion. After laminectomy and decompression were done, neuromonitoring signals...