Evaluation of the influenza vaccine protection in the house dust mite-induced chronic allergic asthma mice model and the evaluation of squalene oil in water emulsion as an adjuvant candidate

2 months 1 week ago
So Yeon Ahn
CONCLUSION: The immune response after split inactivated A/PR8 vaccine differed between asthma and naïve mice, particularly in terms of antibody activity and T cell populations. This study enhances our understanding of how asthma status may influence the effectiveness of influenza vaccine and offers insights into the AddaVax™-induced eosinophilic inflammation, guiding the development of virus vaccine strategies for both healthy individuals and asthma patients.

Global Profiles of Positive Youth Development: A Person-Oriented Analysis among Emerging Adults Living in 21 Countries

2 months 1 week ago
Jet Uy Buenconsejo
Although global research on the 5Cs model of Positive Youth Development (PYD; competence, confidence, connection, character, and caring) has expanded in recent years, there is a lack of understanding about distinct and consistent PYD profiles across youth from diverse socio-cultural contexts. To address this gap, this study utilized a person-oriented analytic approach to examine the PYD profiles of 11,481 emerging adults (M^(age) = 21.77; SD^(age) = 2.74; 68.66% females) from 21 countries in...

"We Were Still Left in the Back Field, Not Knowing": Pediatric Cancer Patients and Parents Describe Obstacles to Prognostic Communication

2 months 1 week ago
Adriana Areizaga Ayala
CONCLUSION: Many patients/parents perceived prognostic disclosure to be suboptimal and identified specific features underpinning poor-quality prognostic communication. These findings will inform future collaborative research with patients, parents, and multidisciplinary clinicians to codesign an intervention that individualizes prognostication to align with patient/parent preferences for receiving information and fostering connection.